Sex Hormone Binding Globulin (SHBG)*

Hormones are not always present in free form in the blood as most hormones need specific proteins that can transport them and regulate the actions of hormones. One of the main proteins in this context is Sex Hormone Binding Globulin (SHBG).

The Sex Hormone Binding Globulin (SHBG) Test is used for measuring the level of SHBG in the human blood. Correct binding of SHBG with hormones such as testosterone and estrogen helps physicians to understand how available the hormones are for the organism.

At City Imaging, we perform SHBG testing accurately thanks to our high technology laboratories and strict quality management standards. If you experience hormone imbalance problems or you have to do a fertility assessment, we guarantee precise and timely results of your test. The average price of a Sex Hormone Binding Globulin Test is between INR 2000 and INR 2800.

What Is the SHBG Test?

The SHBG test, or Sex Hormone Binding Globulin Test, is a test that helps to measure the amount of SHBG, which is a protein that is produced by the liver.

This protein binds a variety of hormones like:

• Testosterone
• Dihydrotestosterone
• Estrogen

Once the hormones bind to SHBG, they are inactive in the body. Thus, only free hormones can be used for body functions.

Therefore, measurement of SHBG levels helps doctors interpret testosterone and estrogen levels in the blood better when there are some symptoms that are related to hormones that do not match the results.

Why is Sex Hormone Binding Globulin (SHBG) important?

Sex Hormone Binding Globulin or SHBG performs a vital function as a natural modulator of hormone functioning. High SHBG levels mean that free testosterone amounts are lower than normal, even if total testosterone is normal. The opposite is the case with low SHBG levels, which increase free testosterone circulation and may cause hormonal problems.

As a result, SHBG testing is extremely informative regarding the state of a person's hormonal system and can help establish accurate levels of sex hormones.

Why is the SHBG Test done?

Doctors recommend the SHBG Test for various medical reasons. It is commonly used to:

• Investigate symptoms of hormone imbalance
• Evaluate infertility in men and women
• Assess low testosterone levels
• Diagnose high testosterone levels
• Help identify polycystic ovary syndrome
• Evaluate menstrual irregularities
• Investigate erectile dysfunction
• Assess reduced libido
• Monitor hormone therapy
• Evaluate liver disorders
• Diagnose endocrine disorders
• Assist in evaluating thyroid disease

What are the symptoms that may require an SHBG Test?

Your healthcare provider may recommend the SHBG Test if you experience:

In Men

• Low sex drive
• Erectile dysfunction
• Infertility
• Reduced muscle mass
• Fatigue
• Decreased facial or body hair
• Mood changes
• Low testosterone symptoms

In Women

• Irregular menstrual cycles
• Excess facial hair
• Acne
• Difficulty becoming pregnant
• Hair thinning
• Symptoms of PCOS
• Unexplained weight gain
• Hormonal imbalance

Who should get the SHBG Test?

SHBG assay may be indicated for:

• Men with testosterone deficiency suspected
• Women with symptoms of PCOS
• Couples seeking fertility evaluation
• Patients receiving hormone replacement therapy
• People with unexplained hormonal symptoms
• Patients with disorders of the thyroid
• People with chronic liver disease
• Individuals with obesity
• Patients with disorders of the pituitary gland

How is the SHBG Test performed?

The procedure includes:

1. A healthcare professional cleans the skin over a vein.
2. A sterile needle is inserted into the vein.
3. A small blood sample is collected.
4. The sample is sent to the laboratory.
5. SHBG levels are measured using advanced laboratory techniques.
6. The results are reviewed and shared with your doctor.

Do you need any preparation for Sex Hormone Binding Globulin Test?

Your doctor may recommend:

• Fasting if additional hormone tests are being performed.
• Informing the laboratory about medications.
• Avoiding unnecessary hormonal medications unless instructed otherwise.
• Following any preparation guidelines provided by your healthcare provider.

How to understand SHBG Test results?

SHBG levels vary according to:

• Age
• Sex
• Hormonal status
• Pregnancy
• Overall health
• Laboratory reference ranges

Below is the table which shows the possible Interpretation of SHBG results

What are the factors that may increase SHBG levels?

These may include:

• Aging
• Pregnancy
• Hyperthyroidism
• Liver disease
• Estrogen therapy
• Certain medications
• Significant weight loss

What are the factors that may decrease SHBG levels?

Following are the factors that may decrease SHBG levels: 

• Obesity
• Insulin resistance
• Type 2 diabetes
• Hypothyroidism
• Polycystic Ovary Syndrome
• High testosterone levels
• Use of anabolic steroids
• Cushing's syndrome

What are the conditions associated with abnormal SHBG Levels?

Abnormal SHBG levels can provide valuable clues about underlying medical conditions.

Low SHBG levels may be seen in:

• Polycystic Ovary Syndrome
• Obesity
• Type 2 diabetes
• Metabolic syndrome
• Hypothyroidism
• Cushing's syndrome
• High androgen levels
• Non-alcoholic fatty liver disease

High SHBG levels may be seen in:

• Hyperthyroidism
• Liver cirrhosis
• Chronic liver disease
• Pregnancy
• Eating disorders
• HIV infection
• Estrogen therapy
• Aging

What are the benefits of the SHBG Test?

This SHBG test has various benefits. Some important benefits are:

• Helps assess testosterone and estrogen activity.
• Supports the diagnosis of hormonal disorders.
• Assists in evaluating infertility.
• Helps diagnose PCOS.
• Supports the monitoring of hormone replacement therapy.
• Aids in evaluating thyroid and liver disorders.
• Requires only a simple blood sample.
• Safe, quick, and minimally invasive.

What are the limitations of the SHBG Test?

Despite the usefulness of the SHBG Test, it does have its limitations, which are listed below:

• The test does not measure the levels of free testosterone or estrogen directly.
• Results must always be analysed in combination with other hormonal tests.
• Other medications or diseases can influence SHBG levels.
• Normality values for SHBG can vary based on age, sex, and methodological approach used.
• Other investigations might be necessary to find out the cause of abnormal results.

Which Sex Hormone Binding Globulin Test centre is near me?

City Imaging is near me in Delhi for Sex Hormone Binding Globulin test. The diagnostic centre has advanced machines with expert doctors for accurate results. The testing price is also affordable and patients can book the test online by visiting the website.

Are there any risks with the SHBG test?

The SHBG Test is a routine blood test and is considered very safe.

Some people may experience minor side effects, including:

• Mild pain during blood collection
• Slight bruising at the needle site
• Temporary swelling
• Rarely, lightheadedness

Why choose City Imaging for the SHBG Test?

When you choose City Imaging, you benefit from:

• Advanced diagnostic laboratory technology
• Experienced laboratory professionals
• High-quality testing standards
• Accurate and dependable reports
• Quick turnaround times
• Hygienic and comfortable sample collection
• Affordable diagnostic services
• Compassionate, patient-focused care

How to book Sex Hormone Binding Globulin Test online at City Imaging?

A patient can schedule their Sex Hormone Binding Globulin Test on City Imaging's website or by calling them for assistance in making an appointment. The technician also visits your house to collect samples by booking home collections at the website. Also, reports are transferred to patients in soft copy so visiting lab centres is not necessary.

What is the price of Sex Hormone Binding Globulin Test in Delhi?

The Sex Hormone Binding Globulin Test can be performed in Delhi at a price that ranges from INR 2000 to INR 2800. The price may vary slightly depending on the machine used, location and type of test.

Frequently Asked Questions (FAQs)

Is fasting mandatory for the SHBG Test?

Fasting is rarely necessary. Nonetheless, if your physician is conducting additional hormone or metabolic tests along with SHBG then fasting may be suggested. You have to follow whatever your medical practitioner advises.

Why should one go for SHBG Testing in City Imaging?

City Imaging has the best testing facilities, experienced specialists, strict quality control, quick delivery of results, and patient-oriented care.

Why perform the SHBG Test along with testosterone tests?

SHBG attaches to testosterone in the bloodstream. The combination of SHBG and total testosterone allows us to assess the level of free testosterone accurately and gives useful insight into hormone levels.

Can women undergo the SHBG Test?

Yes. The test is used for the evaluation of hormonal alterations in females, as well as the diagnosis of Polycystic Ovary Syndrome (PCOS).

Are there other designations for the SHBG Test?

The test is also named as Sex Hormone Binding Globulin Test.